Metalloporphyrins: Radioprotector and Radiosensitizer

Y Alzarie, O Badary, S Nofal - Journal of Advanced Pharmacy …, 2021 - journals.ekb.eg
… Three lead manganese porphyrins compounds have been … -2-PyP5+ showed antitumor
effect by itself and in combination … cells to IR and the underlying mechanisms of this process. In …

[HTML][HTML] H2O2-Driven Anticancer Activity of Mn Porphyrins and the Underlying Molecular Pathways

I Batinic-Haberle, A Tovmasyan, Z Huang… - … medicine and cellular …, 2021 - hindawi.com
… The tumor radiosensitizing effect of MnP was discussed with … studies, we only looked at the
anticancer effect of MnTE-2-PyP5… fully comprehend the mechanism of the anticancer action of …

Manganese porphyrin and radiotherapy improves local tumor response and overall survival in orthotopic murine mammary carcinoma models

MK Boss, RE Oberley-Deegan… - Radiation …, 2021 - meridian.allenpress.com
… compounds, known as manganese porphyrins (MnPs), have … studies have focused on local
effects of MnPs and radiation; … that these primary tumor treatment effects would result in a …

[HTML][HTML] A Redox-active Mn Porphyrin, MnTnBuOE-2-PyP5+, Synergizes with Carboplatin in Treatment of Chemoresistant Ovarian Cell Line

L Chaiswing, C Yarana, W St Clair… - … Medicine and Cellular …, 2022 - hindawi.com
… Choi, GH Lee et al., “Mechanism of the antitumor and radiosensitizing effects of a
manganese porphyrin, MnHex-2-PyP,” Antioxidants & Redox Signaling, vol. 27, no. 14, pp. …

[HTML][HTML] MnTnHex-2-PyP5+, Coupled to Radiation, Suppresses Metastasis of 4T1 and MDA-MB-231 Breast Cancer via AKT/Snail/EMT Pathways

SW Shin, C Choi, H Kim, Y Kim, S Park, SY Kim… - Antioxidants, 2021 - mdpi.com
… the mechanism of action of Mn porphyrinseffect demonstrated in previous studies [25].
We anticipate that the insights into the anticancer and antimetastatic potentials of Mn porphyrins

… Sequencing Reveals Functional Heterogeneity of Tumor and Immune Cells in Response to Combined Treatment with Manganese Porphyrins, Mntnbuoe-2-Pyp5+ …

SU Noh, J Lim, SW Shin, Y Kim… - Mntnbuoe-2-Pyp5+ … - papers.ssrn.com
… -2-PyP5+ radiosensitizes tumor cells and inhibits metastasis. … Previously, we explored the
anticancer potency and metabolic … of the molecular mechanisms of Mn porphyrins has largely …

Nutrition and melanoma: the contribution of trace elements in onset, progression, and treatment of melanoma

R Lei, X Liu, J Wu - Nutrition Reviews, 2023 - academic.oup.com
… -1 checkpoints, respectively, to exert antitumor effects. Although immune checkpoint inhibitors
Manganese porphyrin Mn porphyrin acts as a radiosensitizer. Exposure of tumor cells to …

Avasopasem manganese synergizes with hypofractionated radiation to ablate tumors through the generation of hydrogen peroxide

BJ Sishc, L Ding, TK Nam, CD Heer… - Science translational …, 2021 - science.org
… Less explored are the potential anticancer effects of selective … porphyrin dismutase mimetics
exhibit radiosensitizing effects … , this mechanism allows for a robust radiosensitizing effect for …

Manganese Porphyrins as Pro-Oxidants in High-Molar-Mass Hyaluronan Oxidative Degradation

K Valachová, P Rapta, I Batinic-Haberle… - Green Chemistry and …, 2020 - taylorfrancis.com
… antioxidative or pro-oxidative effects of Mn(II) ions and Mn-porphyrins such as Mn(III)…
Mechanism of the antitumor and radiosensitizing effects of a manganese porphyrin, MnHex-2-PyP

Mn porphyrins as a novel treatment targeting sickle cell NOXs to reverse and prevent acute vaso-occlusion in vivo

M Thamilarasan, R Estupinan… - Blood …, 2020 - ashpublications.org
… redox-active manganese (Mn) porphyrins MnTnBuOE-2-… mechanisms by Mn porphyrins
would result in decreased ROS levels. Although the preferred mode of action of Mn porphyrins